If you’ve ever wondered why you take off the pounds, only to put them back on again, there is now scientific evidence to support the frustrating seesaw known as body weight.

Obesity is a major problem for many, many Americans. (According to the Harvard School of Public Health, obesity is defined as a body mass index (BMI) of 30 or higher. Overweight is defined as a BMI of 25 to 29.9. The BMI for healthy weight is 18.5 to 24.9.)

In fact, according to the Centers for Disease Control and Prevention, more than 29 million Americans have diabetes (a chronic disease defined by excess weight and the body’s inability to maintain healthy blood sugar levels). And 1 in 4 people doesn’t know of his or her condition. That’s about 1 out of every 11 people.

Also astonishing: Another 86 million Americans are prediabetic (their blood sugar levels are higher than normal but not so high as to be classified as type 2 diabetes). Together, 115 million Americans are at severe risk from this chronic disease, even early death, blindness, heart disease, and stroke. Their stress levels are also maxed, because they can’t seem to maintain a healthy weight.

I have patients who are diabetic and prediabetic, and the first thing I tell them is that we will begin to manage their weight – through nutrition, exercise, medications, and lifestyle choices like meditation to reduce stress. Stress sets up a domino effect of stress>eat>more stress>more eating. And American teenagers, in many cases, don’t even know they are overweight; yet, 208,000 Americans younger than 20 years have been diagnosed with diabetes (type 1 or 2).

It doesn’t have to be this way. And it’s heartbreaking to see an obese or overweight patient lose all will and heart because they cannot keep their weight in a reasonable range.

The Latest Research

According to a brand new study out of King’s College London and recently published in the American Journal of Public Health, the average obese woman has an approximate 1 in 124 chance of returning to a normal weight. For men, the odds are worse: 1 in 210. “The Washington Post” recently highlighted this study that analyzed health records of more than 278,000 people living in England over a nine-year period.

It gets worse. Obese men and women have little chance of achieving even a 5 percent weight loss in any given year: 1 in 10 for women and 1 in 12 for men.

A study author, Professor Martin Gulliford, said, “Current strategies to tackle obesity, which mainly focus on cutting calories and boosting physical activity, are failing to help the majority of obese patients to shed weight and maintain the weight loss.”

My answer is very simple: You must address weight loss at the genetic level, where the engine of change is initiated and maintained.

The Gene Therapy Solution: Encouraging Apoptosis

In my latest book, The Gene Therapy Plan, I lay out the causes and solutions for excess weight. Apoptosis is natural cell death, programmed in our bodies, whereby billions of cells die off and are neatly disposed of every day. As part of the body’s programmed housecleaning mechanism, more and more research is looking at the possibility of encouraging natural cell death – so much better than waiting for calories to be burned or not ingested in the first place.

As I mention in my chapter of Obesity, preliminary evidence suggests that certain compounds can encourage apoptosis in fat cells: the right foods are the rescue.

Three Foods to Help


Garlic has been shown to encourage cell death through a sulfur-containing compound called ajoene that activates hydrogen peroxide. This operates at the genetic level and is good for you in so many ways that it’s a non-brainer for both fat-related and general health.

Guggulsterone & Peperine

Scientists report that the active compound of a gum resin called guggulsterone, commonly used in the traditional medicine of India, induces fat cell death and blocks formation of fat cells. Piperine, a major component in black pepper, also appears to block development of new fat cells.

Genistein: Fava Beans & Soybeans

Genistein is an estrogen-like compound found in plants such as fava beans and soybeans, both of which have been shown to induce apoptosis in fat cells. Important:

The apoptopic effects appear to be magnified by the addition of vitamin D3. In fact, the combination of D3 and genistein is 200 percent more effective than using genistein alone.


You’ve heard it before, but it bears repeating. If you incorporate regular exercise into your lifestyle, the benefits for weight loss are proven (not to mention overall health and less stress). Don’t make it a chore; make it a choice. Start with simple actions, like walking to work three times a week, using stairs instead of elevators, or hopping off the bus one or two stops earlier.

Once the habit of exercise is ingrained, you’ll find that you feel better (and look better) – encouragement, itself, to keep it up.

My book also outlines specific recipes, including a juice that features celery sticks, blueberries, and green tea – a delicious way to cut fat and get healthier. And because my suggestions work at the genetic level, you can count on sustainable and long-range results. For you – and future generations.

In general, eat low-fat, organic foods, freshly prepared with organic olive oil or coconut oil. You’ll find the natural flavors of these foods make them appealing, as well as efficient for long-range results. Avoid processed foods, packaged snacks, and sugary drinks at all costs. Remember, if you have a “slip,” don’t stress. The stress could set off that seesaw effect, which is best avoided in the first place. Keep exercising and keep eating healthy. You’ll get there.

One step at a time, as they say.

“More than 29 million Americans have diabetes: 1 in 4 doesn’t know,” Centers for Disease Control and Prevention.
“Obesity Prevention Source,” Harvard T. H. Chan School of Public Health, http://www.hsph.harvard.edu/obesity-prevention-source/
Ingraham, Christopher, “One chart shows why it’s nearly impossible to lose weight and keep it off,” Washington Post, July 18, 2015.
Yang, J. Y., et al. “Molecular Mechanisms of Apoptosis Induced by Ajoene in 3T3-L1 Cells,” Obesity 14 no.3 (2006): 388-97.
Yang, J. Y., et al. “Guggulsterone Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3-LI Cells,” Obesity 16 no. 1 (2007): 16-22.
Park, U. H., et al. “Piperine, a Component of Black Pepper, Inhibits Adipogenesis by Antagonizing PPARy Activity in 3T3-L1 Cells,” Journal of Agricultural and Food Chemistry 60, no. 15 (2012): 3853-60.
Rayalam, S., et al. “Phytochemicals and Regulation of the Adipocyte Life Cycle,” Journal of Nutritional Biochemistry 19, no. 11 (2008): 717-26.